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Warm congratulations on longxiang for adding Class II new veterinary drug—Menbutone, which fills the blank of domestic cholagogue for animal use

Release time:


New veterinary drug registration certificate of the People's Republic of China

Certificate No.: (2020) New veterinary drug certificate No.9

New veterinary drug name: Menbutone

Registered classification: Class II

Development organization: Southwest university;Tianjin Ringpu Biotechnology co., Ltd; Hubei Longxiang Pharmaceutical Tech. Co. Ltd.

According to <Animal Medicine Management Regulations>, this veterinary drug meets the regulation, so registration is hereby granted, this certificate is hereby issued.

Date of issue: 2020.3.23


The approval of menbutone filled in the blank of choleric drugs for animals in China

In veterinary clinic, the incidence of digestive diseases in pigs, cattle, sheep and other animals is high. However, gastrointestinal dysfunction, such as loss of appetite, indigestion, constipation, abdominal distension, gastrointestinal relaxation, rumen accumulation, etc, are concomitant or secondary to almost all diseases in animals. Animal dyspepsia can hinder the growth and development of animals, decrease the production performance and even kill them, often causing great economic losses.

The raw materials and preparations of menbutone were approved to be marketed in Germany in 1965, and were approved as cholagogue for animals use by the European veterinary drug products committee in 1996. Menbutone can effectively treat animal dyspepsia, loss of appetite, constipation, abdominal distension and other gastrointestinal dysfunction, improve the digestion and absorption function. It is widely used in pigs, cattle, sheep, goats, horses and dogs for dyspepsia, anorexia, constipation, toxemia, liver and pancreas dysfunction. So far, menbutone preparations are still on the market in Germany, France, the United Kingdom, Spain, Italy, Switzerland, Japan, South Korea and Thailand while the raw materials and preparations are blank in China.

Physicochemical property

Menbutone, whose chemical name is 3-(4-METHOXY-1-NAPHTHOYL)PROPIONIC ACID, is white or almost white crystalline powder, easily soluble in acetone, soluble in trichloromethane, slightly soluble in methanol and ethanol, very slightly soluble in ether, almost insoluble in water, easily soluble in sodium hydroxide solution. Molecular formula is C15H14O4, molecular weight is 258.27.


Menbutone is cholagogue for animals use. It can stimulate the secretion of gastrointestinal digestive juices and increase the secretion of bile by about 2 times, the secretion of gastric juice and pancreatic juice about 5 times of the normal secretion, the secretion of cholate, pepsin, trypsin, pancreatic lipase and pancreatic amylase, promote the digestion and absorption of fat, protein and starch, improve and restore liver metabolism.

It has mild and safe effects, and has no obvious adverse effects on the central nervous system, cardiovascular system, respiratory system, urinary system, digestive system and reproductive system. It has basically no effect on the uterine smooth muscle of female animals, and will not cause adverse reproduction and abortion. It can be used in pregnant animals.

Function and use

For pig dyspepsia, anorexia and constipation abdominal distension and other gastrointestinal dysfunction. This product can be used alone, also can be used as adjuvant therapy drug combination with other drugs.


1. Menbutone powder

[usage and dosage] Internal administration: 10-30mg menbutone/kg bw for pigs, once a day, for 1~5 consecutive days.

[Withdraw period] 6d for pigs

[Precaution for use] This product should not be used on piglets younger than 10 days of age; In case of contact with skin, please rinse as soon as possible.

2. Menbutone injection

[usage and dosage] Intramuscular injection, 10mg menbutone/kg bw for pigs, once a day. If necessary, it can be reused on pigs with severe disease.

[Withdraw period]7d for pigs

[Precaution for use]

a. It is forbidden to be used in pigs with allergy, arrhythmia, high fever or biliary tract obstruction; Banned for cats.

b. This product can be used in the early, middle and lactation stages of pregnancy in pigs, but it is forbidden to be used in the third trimester (after the third trimester).

c. For intramuscular injection, the volume of each injection site should not exceed 20ml.

d. The safe dose range of menbutone is unclear. If a pig has heart block, it can be saved by injecting cardiac drugs.

E. Persons who are allergic to the active ingredients of this product shall not touch this product.